Kathleen Derwin Laboratory

Research

Our research program focuses on identifying the factors that influence healing and clinical outcomes after rotator cuff repair—including demographic, disease, and surgical issues, as well as local biologic factors such as stem and progenitor cell characteristics and inflammatory biomarkers. Our aim is the modification of key factors, either pre-operatively or through surgical treatment, which will lead to better clinical decision-making, patient selection and improved outcomes.

We also investigate extracellular matrix scaffold technologies as a surgical treatment strategy for enhancing healing after rotator cuff repair. We utilize traditional MRI, together with novel CT-based imaging of radiopaque markers, to measure tendon retraction and understand the relationship between structural healing of the tendon and clinical outcomes. Further, we are developing imaging biomarkers to quantify local bone marrow "quality" and guide decision-making about tissue-healing potential and the need for cell-based therapies.

Selected Publications

View publications for Kathleen Derwin, PhD
(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

1. Sahoo S, Stojanovska M, Imrey PB, Jin Y, Bowles RJ, Ho JC, Iannotti JP, Ricchetti ET, Spindler KP, Derwin KA, Entezari V. Changes From Baseline in Patient-Reported Outcomes at 1 Year Versus 2 Years After Rotator Cuff Repair: A Systematic Review and Meta-analysis. Am J Sports Med. 2021 Sep 2:3635465211023967. doi: 10.1177/03635465211023967. Epub ahead of print. PMID: 34473586.
2. Iannotti JP, Jun BJ, Derwin KA, Ricchetti ET. Stepped Augmented Glenoid Component in Anatomic Total Shoulder Arthroplasty for B2 and B3 Glenoid Pathology: A Study of Early Outcomes. J Bone Joint Surg Am. 2021 May 14. doi: 10.2106/JBJS.20.01420. Epub ahead of print. PMID: 33989252.
3. Ma J, Sahoo S, Imrey PB, Jin Y, Baker AR, Entezari V, Ho JC, Iannotti JP, Ricchetti ET, Polster JM, Winalski CS, Derwin KA. Inter-rater agreement of rotator cuff tendon and muscle MRI parameters evaluated preoperatively and during the first postoperative year following rotator cuff repair. J Shoulder Elbow Surg. 2021 Apr 27:S1058-2746(21)00401-8. doi: 10.1016/j.jse.2021.04.021. Online ahead of print.
4. Ricchetti ET, Jun BJ, Jin Y, Ho JC, Patterson TE, Dalton JE, Derwin KA, Iannotti JP. Relationship Between Glenoid Component Shift and Osteolysis After Anatomic Total Shoulder Arthroplasty: Three-Dimensional Computed Tomography Analysis. J Bone Joint Surg Am. 2021 Apr 8. doi: 10.2106/JBJS.20.00833.
5. Jun BJ, Sahoo S, Imrey PB, Baker AR, Erdemir A, Jin Y, Iannotti JP, Entezari V, Ricchetti ET, Bey MJ, Derwin KA. Variability of glenohumeral positioning and bone-to-tendon marker length measurements in repaired rotator cuffs from longitudinal computed tomographic imaging. JSES Int. 2020 Sep 12;4(4):838-847. doi: 10.1016/j.jseint.2020.08.001. eCollection 2020 Dec.
6. Associations of preoperative patient mental health status and sociodemographic and clinical characteristics with baseline pain, function, and satisfaction in patients undergoing primary shoulder arthroplasty. Sahoo S, Derwin KA, Zajichek A; Cleveland Clinic Shoulder Group, Entezari V, Imrey PB, Iannotti JP, Ricchetti ET. J Shoulder Elbow Surg. 2021 May;30(5):e212-e224. doi: 10.1016/j.jse.2020.08.003. Epub 2020 Aug 26.
7. Ricchetti ET, Jun BJ, Jin Y, Entezari V, Patterson TE, Derwin KA, Iannotti JP. Three-dimensional computed tomography analysis of pathologic correction in total shoulder arthroplasty based on severity of preoperative pathology. J Shoulder Elbow Surg. 2021 Feb;30(2):237-249. doi: 10.1016/j.jse.2020.07.033. Epub 2020 Aug 7.
8. Guevara JA, Entezari V, Ho JC, Derwin KA, Iannotti JP, Ricchetti ET. An Update on Surgical Management of the Repairable Large-to-Massive Rotator Cuff Tear. J Bone Joint Surg Am. 2020 Oct 7;102(19):1742-1754. doi: 10.2106/JBJS.20.00177.
9. Sahoo S, Ricchetti ET, Zajichek A; Cleveland Clinic Shoulder Group, Evans PJ, Farrow LD, McCoy BW, Jones MH, Miniaci AA, Sabesan VJ, Schickendantz MS, Seitz WH, Spindler KP, Stearns KL, Strnad G, Turan A, Entezari V, Imrey PB, Iannotti JP, Derwin KA. Associations of Preoperative Patient Mental Health and Sociodemographic and Clinical Characteristics With Baseline Pain, Function, and Satisfaction in Patients Undergoing Rotator Cuff Repairs. Am J Sports Med. 2020 Feb;48(2):432-443. doi: 10.1177/0363546519892570. Epub 2019 Dec 18.
10. Derwin KA, Thomopoulos S. Discovery to delivery in tendon research. J Orthop Res. 2020 Jan;38(1):5-6. doi: 10.1002/jor.24549.
11. Sahoo S, Baker AR, Jun BJ, Erdemir A, Ricchetti ET, Iannotti JP, Derwin KA. A novel radiopaque tissue marker for soft tissue localization and in vivo length and area measurements. PLoS One. 2019 Oct 18;14(10):e0224244. doi: 10.1371/journal.pone.0224244. eCollection 2019.
12. Sahoo S, Ma J, Tastaldi L, Baker AR, Loftis J, Rosen MJ, Derwin KA: Biodegradable hyaluronan hydrogel coatings on acellular dermis grafts - a potential strategy to improve biologic graft durability in hernia repair application: Resorbable hyaluronan hydrogel coatings on acellular dermis grafts - a potential strategy to improve biologic graft durability in hernia repair applications. J Biomed Mater Res B Appl Biomater. 2019 Nov;107(8):2664-2672. doi: 10.1002/jbm.b.34357 (PMID: 30860665)
13. Sahoo S, Mohr J, Strnad GJ, Vega J, Jones M, Schickendantz MS, Farrow L, Spindler KP, Iannotti JP, Ricchetti ET, Derwin KA: Validity and efficiency of a smartphone-based electronic data collection tool for operative data in rotator cuff repair. J Shoulder Elbow Surg. 2019 Jul;28(7):1249-1256. doi: 10.1016/j.jse.2018.12.009 (PMID: 31056396)
14. Derwin KA, Sahoo S, Zajichek A, Strnad G, Spindler KP, Iannotti JP, Ricchetti ET: Tear characteristics and surgeon predict repair technique and suture anchor usage in repair of superior-posterior rotator cuff tendon tears. J Shoulder Elbow Surg. 2019 Jan;28(1):227-236. doi.org/10.1016/j.jse.2018.07.028 (PMID: 30318274)
15. Derwin KA, Galatz LM, Ratcliffe A, Thomopolous S: Enthesis repair: Challenges and opportunities for effective tendon-to-bone healing. J Bone Joint Surg Am. 2018 Aug 15;100(16):e109. doi: 10.2106/JBJS.18.00200 (PMID: 30106830)
16. Ma J, Piuzzi NS, Muschler GF, Iannotti JP, Ricchetti ET, Derwin KA: Biomarkers of Rotator Cuff Disease Severity and Repair Healing. JBJS Rev. 2018 Sep;6(9):e9. doi: 10.2106/JBJS.RVW.17.00178 (PMID: 30252720)
17. Mahylis JM, Entezari V, Karichu J, Richter S, Derwin KA, Iannotti JP, Ricchetti ET. Hemolytic strains of Propionibacterium acnes do not demonstrate greater pathogenicity in periprosthetic shoulder infections. J Shoulder Elbow Surg. 2018 Jun;27(6):1097-1104. doi: 10.1016/j.jse.2017.12.025. Epub 2018 Feb 19. PMID: 29472140
18. Milks RA, Kolmodin JD, Ricchetti ET, Iannotti JP, Derwin KA. Augmentation with a reinforced acellular fascia lata strip graft limits cyclic gapping of supraspinatus repairs in a human cadaveric model. J Shoulder Elbow Surg. 2018 Jun;27(6):1105-1111. doi: 10.1016/j.jse.2017.12.016.
19. Sahoo S, Haskins IN, Huang LC, Krpata DM, Derwin KA, Poulose BK, Rosen MJ. Early Wound Morbidity after Open Ventral Hernia Repair with Biosynthetic or Polypropylene Mesh. J Am Coll Surg. 2017 Oct;225(4):472-480.e1. doi: 10.1016/j.jamcollsurg.2017.07.1067. Epub 2017 Aug 4. PMID: 28826804
20. Sahoo S, Baker AR, Haskins IN, Krpata DM, Rosen MJ, Derwin KA. Assessment of Human Acellular Dermis Graft in Porcine Models for Ventral Hernia Repair. Tissue Eng Part C Methods. 2017 Nov;23(11):718-727. doi: 10.1089/ten.TEC.2017.0238. Epub 2017 Aug 3. PMID: 28602151
21. Ma J, Baker AR, Calabro A, Derwin KA. Exploratory study on the effect of osteoactivin on muscle regeneration in a rat volumetric muscle loss model. PLoS One. 2017 Apr 20;12(4):e0175853. doi: 10.1371/journal.pone.0175853. eCollection 2017. PMID: 28426701 Free PMC article.
22. Sahoo S, Baker AR, Haskins IN, Krpata DM, Rosen MJ, Derwin KA. Development of a critical-sized ventral hernia model in the pig. J Surg Res. 2017 Apr;210:115-123. doi: 10.1016/j.jss.2016.10.026. Epub 2016 Nov 4. PMID: 28457317 
23. Frangiamore SJ, Saleh A, Grosso MJ, Farias Kovac M, Zhang X, Daly TM, Bauer TW, Derwin KA, Iannotti JP, Ricchetti ET.Neer Award 2015: Analysis of cytokine profiles in the diagnosis of periprosthetic joint infections of the shoulder. J Shoulder Elbow Surg. 2017 Feb;26(2):186-196. doi: 10.1016/j.jse.2016.07.017. Epub 2016 Oct 5. PMID: 27720413 
24. Kovacevic D, Baker AR, Staugaitis SM, Kim MS, Ricchetti ET, Derwin KA. Development of an Arthroscopic Joint Capsule Injury Model in the Canine Shoulder. PLoS One. 2016 Jan 25;11(1):e0147949. doi: 10.1371/journal.pone.0147949. eCollection 2016. PMID: 26808837 Free PMC article. 
25. Kim MS, Kovacevic D, Milks RA, Jun BJ, Rodriguez E, DeLozier KR, Derwin KA, Iannotti JP. Bone Graft Substitute Provides Metaphyseal Fixation for a Stemless Humeral Implant. Orthopedics. 2015 Jul 1;38(7):e597-603. doi: 10.3928/01477447-20150701-58. PMID: 26186322
26. Thomopoulos S, Parks WC, Rifkin DB, Derwin KA. Mechanisms of tendon injury and repair. J Orthop Res. 2015 Jun;33(6):832-9. doi: 10.1002/jor.22806. Epub 2015 Mar 2. PMID: 25641114 Free PMC article. Review.
27. Leigh DR, Kim MS, Kovacevic D, Baker AR, Tan CD, Calabro A, Derwin KA. Human fascia lata ECM scaffold augmented with immobilized hyaluronan: inflammatory response and remodeling in the canine body wall and shoulder implantation sites. J Biomater Sci Polym Ed. 2015;26(1):1-15. doi: 10.1080/09205063.2014.975394. Epub 2014 Nov 17. PMID: 25400204 Free PMC article. 
28. Sahoo S, DeLozier KR, Erdemir A, Derwin KA. Clinically relevant mechanical testing of hernia graft constructs. J Mech Behav Biomed Mater. 2015 Jan;41:177-88. doi: 10.1016/j.jmbbm.2014.10.011. Epub 2014 Oct 27. PMID: 25460414
29. Ma J, Sahoo S, Baker AR, Derwin KA. Investigating muscle regeneration with a dermis/small intestinal submucosa scaffold in a rat full-thickness abdominal wall defect model. J Biomed Mater Res B Appl Biomater. 2015 Feb;103(2):355-64. doi: 10.1002/jbm.b.33166. Epub 2014 May 29.PMID: 24889422
30. Sahoo S, DeLozier KR, Dumm RA, Rosen MJ, Derwin KA. Fiber-reinforced dermis graft for ventral hernia repair. J Mech Behav Biomed Mater. 2014 Jun;34:320-9. doi: 10.1016/j.jmbbm.2014.03.001. Epub 2014 Mar 15. PMID: 24704969
31. Mesiha MM, Derwin KA, Sibole SC, Erdemir A, McCarron JA. The biomechanical relevance of anterior rotator cuff cable tears in a cadaveric shoulder model. J Bone Joint Surg Am. 2013 Oct 16;95(20):1817-24. doi: 10.2106/JBJS.L.00784.
32.  McCarron JA, Derwin KA, Bey MJ, Polster JM, Schils JP, Ricchetti ET, Iannotti JP. Failure with continuity in rotator cuff repair "healing". Am J Sports Med. 2013 Jan;41(1):134-41. doi: 10.1177/0363546512459477.
33.  Leigh DR, Mesiha M, Baker AR, Walker E, Derwin KA. Host response to xenograft ECM implantation is not different between the shoulder and body wall sites in the rat model. J Orthop Res. 2012 Nov;30(11):1725-31. doi: 10.1002/jor.22149.
34. Baker AR, McCarron JA, Tan CD, Iannotti JP, Derwin KA. Does augmentation with a reinforced fascia patch improve rotator cuff repair outcomes? Clin Orthop Relat Res. 2012 Sep;470(9):2513-21. doi: 10.1007/s11999-012-2348-x.
35.  McCarron JA, Milks RA, Mesiha M, Aurora A, Walker E, Iannotti JP, Derwin KA. Reinforced fascia patch limits cyclic gapping of rotator cuff repairs in a human cadaveric model. J Shoulder Elbow Surg. 2012 Dec;21(12):1680-6. doi: 10.1016/j.jse.2011.11.039.
36. Sahoo S, Greeson CB, McCarron JA, Milks RA, Aurora A, Walker E, Iannotti JP, Derwin KA. Effect of pretension and suture needle type on mechanical properties of acellular human dermis patches for rotator cuff repair..J Shoulder Elbow Surg. 2012 Oct;21(10):1413-21. doi: 10.1016/j.jse.2011.10.028.
37. Ricchetti ET, Aurora A, Iannotti JP, Derwin KA. Scaffold devices for rotator cuff repair. J Shoulder Elbow Surg. 2012 Feb;21(2):251-65. doi: 10.1016/j.jse.2011.10.003.
38. Bey MJ, Derwin KA. Measurement of in vivo tendon function. J Shoulder Elbow Surg. 2012 Feb;21(2):149-57. doi: 10.1016/j.jse.2011.10.023.
39. Chin L, Calabro A, Walker E, Derwin KA. Mechanical properties of tyramine substituted-hyaluronan enriched fascia extracellular matrix. J Biomed Mater Res A. 2012 Mar;100(3):786-93. doi: 10.1002/jbm.a.34025.
40. Aurora A, Mesiha M, Tan CD, Walker E, Sahoo S, Iannotti JP, McCarron JA, Derwin KA. Mechanical characterization and biocompatibility of a novel reinforced fascia patch for rotator cuff repair. J Biomed Mater Res A. 2011 Nov;99(2):221-30. doi: 10.1002/jbm.a.33179.
41. Aurora A, McCarron JA, van den Bogert AJ, Gatica JE, Iannotti JP, Derwin KA. The biomechanical role of scaffolds in augmented rotator cuff tendon repairs. J Shoulder Elbow Surg. 2012 Aug;21(8):1064-71. doi: 10.1016/j.jse.2011.05.014.
42. Leigh DR, Baker AR, Mesiha M, Rodriguez ER, Tan CD, Walker E, Derwin KA. Effect of implantation site and injury condition on host response to human-derived fascia lata ECM in a rat model.
43. J Orthop Res. 2012 Mar;30(3):461-7. doi: 10.1002/jor.21529.
44. Chin L, Calabro A, Rodriguez ER, Tan CD, Walker E, Derwin KA. Characterization of and host response to tyramine substituted-hyaluronan enriched fascia extracellular matrix. J Mater Sci Mater Med. 2011 Jun;22(6):1465-77. doi: 10.1007/s10856-011-4325-4.
45. Bey MJ, Kline SK, Baker AR, McCarron JA, Iannotti JP, Derwin KA. Estimation of dynamic, in vivo soft-tissue deformation: experimental technique and application in a canine model of tendon injury and repair. J Orthop Res. 2011 Jun;29(6):822-7. doi: 10.1002/jor.21315.
46. McCarron JA, Milks RA, Chen X, Iannotti JP, Derwin KA. Improved time-zero biomechanical properties using poly-L-lactic acid graft augmentation in a cadaveric rotator cuff repair model. J Shoulder Elbow Surg. 2010 Jul;19(5):688-96. doi: 10.1016/j.jse.2009.12.008.
47. Derwin KA, Badylak SF, Steinmann SP, Iannotti JP. Extracellular matrix scaffold devices for rotator cuff repair. J Shoulder Elbow Surg. 2010 Apr;19(3):467-76. doi: 10.1016/j.jse.2009.10.020.
48. Derwin KA, Baker AR, Iannotti JP, McCarron JA. Preclinical models for translating regenerative medicine therapies for rotator cuff repair. Tissue Eng Part B Rev. 2010 Feb;16(1):21-30. doi: 10.1089/ten.TEB.2009.0209.
49. Derwin KA, Codsi MJ, Milks RA, Baker AR, McCarron JA, Iannotti JP. Rotator cuff repair augmentation in a canine model with use of a woven poly-L-lactide device. J Bone Joint Surg Am. 2009 May;91(5):1159-71. doi: 10.2106/JBJS.H.00775.
50. Farhat WA, Chen J, Haig J, Antoon R, Litman J, Sherman C, Derwin K, Yeger H. Porcine bladder acellular matrix (ACM): protein expression, mechanical properties. Biomed Mater. 2008 Jun;3(2):025015. doi: 10.1088/1748-6041/3/2/025015.
51. Leigh DR, Abreu EL, Derwin KA. Changes in gene expression of individual matrix metalloproteinases differ in response to mechanical unloading of tendon fascicles in explant culture. J Orthop Res. 2008 Oct;26(10):1306-12. doi: 10.1002/jor.20650.
52. Androjna C, Gatica JE, Belovich JM, Derwin KA. Oxygen diffusion through natural extracellular matrices: implications for estimating "critical thickness" values in tendon tissue engineering.Tissue Eng Part A. 2008 Apr;14(4):559-69. doi: 10.1089/tea.2006.0361.
53. Abreu EL, Leigh D, Derwin KA. Effect of altered mechanical load conditions on the structure and function of cultured tendon fascicles. J Orthop Res. 2008 Mar;26(3):364-73. doi: 10.1002/jor.20520.
54. Derwin KA, Baker AR, Spragg RK, Leigh DR, Farhat W, Iannotti JP. Regional variability, processing methods, and biophysical properties of human fascia lata extracellular matrix. J Biomed Mater Res A. 2008 Feb;84(2):500-7. doi: 10.1002/jbm.a.31455.
55. Aurora A, McCarron J, Iannotti JP, Derwin K. Commercially available extracellular matrix materials for rotator cuff repairs: state of the art and future trends. J Shoulder Elbow Surg. 2007 Sep-Oct;16(5 Suppl):S171-8. doi: 10.1016/j.jse.2007.03.008. Epub 2007 Jun 8.
56. Derwin KA, Baker AR, Codsi MJ, Iannotti JP. Assessment of the canine model of rotator cuff injury and repair. J Shoulder Elbow Surg. 2007 Sep-Oct;16(5 Suppl):S140-8. doi: 10.1016/j.jse.2007.04.002.
57. Androjna C, Spragg RK, Derwin KA. Mechanical conditioning of cell-seeded small intestine submucosa: a potential tissue-engineering strategy for tendon repair. Tissue Eng. 2007 Feb;13(2):233-43. doi: 10.1089/ten.2006.0050.
58. Derwin KA, Baker AR, Spragg RK, Leigh DR, Iannotti JP. Commercial extracellular matrix scaffolds for rotator cuff tendon repair. Biomechanical, biochemical, and cellular properties. J Bone Joint Surg Am. 2006 Dec;88(12):2665-72. doi: 10.2106/JBJS.E.01307.
59. Iannotti JP, Codsi MJ, Kwon YW, Derwin K, Ciccone J, Brems JJ. Porcine small intestine submucosa augmentation of surgical repair of chronic two-tendon rotator cuff tears. A randomized, controlled trial. J Bone Joint Surg Am. 2006 Jun;88(6):1238-44. doi: 10.2106/JBJS.E.00524.
60. Safran O, Derwin KA, Powell K, Iannotti JP. Changes in rotator cuff muscle volume, fat content, and passive mechanics after chronic detachment in a canine model. J Bone Joint Surg Am. 2005 Dec;87(12):2662-70. doi: 10.2106/JBJS.D.02421.
61. DeFranco MJ, Derwin K, Iannotti JP. New therapies in tendon reconstruction. J Am Acad Orthop Surg. 2004 Sep-Oct;12(5):298-304. doi: 10.5435/00124635-200409000-00004.
62. Robinson PS, Lin TW, Reynolds PR, Derwin KA, Iozzo RV, Soslowsky LJ. Strain-rate sensitive mechanical properties of tendon fascicles from mice with genetically engineered alterations in collagen and decorin. J Biomech Eng. 2004 Apr;126(2):252-7. doi: 10.1115/1.1695570.