John O‘Toole, MD
Staff
Location: Cleveland Clinic Main Campus
Research
Biography
Education & Professional Highlights
Education & Fellowships
Fellowship - University of Michigan
Faculty Appointment in Nephrology
Ann Arbor, MI USA
2007
Fellowship - University of Michigan
Nephrology
Ann Arbor, MI USA
2003
Residency - University of Iowa Hospitals and Clinics
Internal Medicine/ Nephrology
Iowa City, IA USA
2001
Medical Education - University of Cincinnati Medical Center/University Hospital
Cincinnati, OH USA
1998
Undergraduate - Boston College
Chestnut Hill, MA USA
1992
Certifications
- Internal Medicine
- Internal Medicine - Nephrology
Research
John O'Toole is an adult nephrologist at the Cleveland Clinic and is focused on basic and translational research investigating the molecular genetic mechanisms of chronic kidney disease.
He is participating in several NIH-sponsored observational trials characterizing rare and common forms of kidney disease using high-throughput -omics approaches to redefine kidney disease on a molecular level. His laboratory uses molecular biologic approaches and model systems to study the biologic mechanisms underlying genetic variation that has been associated with increased risk for kidney disease.
The laboratory is actively investigating the pathobiology of APOL1 genetic variants that are common in African ancestral populations and are associated with common kidney disease, such as kidney disease attributed to hypertension as well as less common forms of kidney disease, such as focal segmental glomerulosclerosis, HIV-associated nephropathy, and lupus nephritis.
Our Team
Selected Publications
View publications for John O‘Toole, MD
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Careers
Research News
Drs. Bruggeman, Sedor and O’Toole will investigate the pathogenic mechanisms of chronic kidney disease to develop greater understanding of genetic susceptibility and develop new treatment strategies.
Dr. Bruggeman shows in a new study that genetic variants to the APOL1 gene are associated with increased risk for pregnancy-induced hypertension in African American women.
By studying a model of HIV-associated nephropathy, a group of kidney disease researchers and clinicians discovered that in patients with the APOL1 risk gene, the presence of an environmental stressor, like a virus, can trigger cell changes that lead to chronic kidney diseases.
Five of the 29 projects selected for 2019 grant funding as part of the Annual Fund program included Lerner Research Institute researchers.