About Us
Our understanding of human physiology and disease susceptibility is dramatically changing. We now recognize that our bodies integrate the biology of our human cells and genome with the trillions of bacteria that live within and on us. In fact, a significant component of disease is derived from these microbial communities. Defining the processes and events responding to our microbiota offers new insights into disease processes, defines new relationships governing the natural history of human disease, and offers new approaches to treat and prevent disease
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Research News
Dr. Hazen identified the gbu gene cluster as a potential therapeutic target for diet-associated cardiovascular disease, and showed that dietary modifications may also help reduce risk.
Drs. Hazen and Zhu found that elevated levels of blood TMAO are associated with larger infarct volume and poorer functionality following injury in preclinical stroke models, offering the first evidence that the gut microbiome directly modulates stroke severity.
Dr. Ahern will investigate the interplay between the gut microbiome and host immune response to understand how novel probiotic strategies may help modulate inflammation and one day be used to treat inflammatory bowel disease.